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KMID : 0385920130240060750
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Journal of the Korean Society of Emergency Medicine
2013 Volume.24 No. 6 p.750 ~ p.756
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Effect of Intravenous Fat Emulsion on Glyphosate Surfactant Herbicide-Induced Shock in a Rat Model- A Preliminary Study
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Cho Byul-NimHee
Ryu Seung
Yoo In-Sool
Ahn Hong-Joon
Kim Gun-Dong
Kim Hoon
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Abstract
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Purpose: Decontamination and supportive care are general types of treatment for glyphosate surfactant herbicide (GlySH) intoxication. However, no particular treatment for refractory shock has been established as a conventional therapy. Therefore, this study examined whether intravenous fat emulsion therapy (IFE) is effective on GlySHinduced shock.
Methods: This preliminary study was conducted on 10 rats. After anesthesia and catheterization, shock was induced by GlySH infusion. After a stabilization period, animals were randomized to receive intravenous normal saline (Group 1) or 20% lipid emulsion (Group 2).
Results: In the shock state, there was no significant difference between the two groups for systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP). In the post-management state, there was no significant difference between the two groups for SBP and MAP. However, there was a significant difference for DBP (Group 1, median 72.5 (IQR 52.8-74.6) mmHg; Group 2, median 77.6 (IQR 74.8-98.3) mmHg, p=0.016), SBP variation (Group 1, median 5.5 (IQR 1.6-11.1) mmHg; Group 2, median 25.6 (IQR 15.5-42.9) mmHg, p=0.008); DBP variation (Group 1, median -1.02 (IQR -4.69-11.0) mmHg; Group 2, median 21.1 (IQR 14.0-43.2) mmHg, p=0.008); MAP variation (Group 1, median 1.15 (IQR -2.6-11.0) mmHg; Group 2, median 23.2 (IQR 14.2-42.8) mmHg, p=0.008).
Conclusion: The IFE increased blood pressure when shock was induced using GlySH. However, further studies are required to determine what components induced the shock and permitted a response to the IFE.
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KEYWORD
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Glyphosate, Fat emulsions, Intravenous, Shock
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